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Forty-three cents out of every dollar of industry costs goes towards the manufacturing process, in contrast to only four cents spent on purchasing tobacco leaf itself (Eriksen et al

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Several reasons can be envisioned for this, including the possibility that individuals in group (i) may have more muscle mass or lean body mass, a gradual decline in U-Cr excretion with age [54] that may have occurred in group (ii), and the possible association between arsenic exposure and U-Cr concentrations (low U-Cr levels in groups ((iii), (iv)), as some studies have reported an association between As metabolism and the relative proportion of di-methyl arsenical species (DMAs) in urine with U-Cr [55,56,57,58]

This difference is normal and most people adjust within 2-4 weeks