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Nicotine reaches your brain within 10 seconds of when it enters your body

Its therapeutic effects in this setting include: acute anaphylactic reactions beta-2 mediated bronchodilation beta-2 mediated decrease in release of inflammatory mediators by mast cells & basophils (Peachell 2006) alpha-1 & alpha-2 mediated vasoconstriction & resulting decrease of mucosal edema in the upper airway increased blood pressure (to counteract histamine-induced hypotension) e.g

When the e-cigarette liquid broke down, it produced both formaldehyde and formaldehyde-releasing agents, a troubling result when you consider that formaldehyde is a known carcinogen