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Suter et al., 2010), can damage DNA by causing double-stranded breaks, as shown in mouse embryonic stem cells exposed to cigarette-smoke condensate (Mortusewicz et al., 2005), which methylates CpGs adjacent to the repaired nucleotides ( nicotine effects on gene expression (Lee and DAlonzo, 1993)

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Studies have demonstrated that CSE can affect the expression of cyclooxygenase-2 in HPVECs, subsequently affecting the production of prostaglandins