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Aside from losing its tumor suppressor function, mutant p53 (mutp53) often acquires inherent, novel oncogenic functions, which is termed gain-of-function

10.1016/j.yrtph.2006.09.004 [DOI] [PubMed] [Google Scholar] Willis D

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But the same holds true of the less typical English tobaccos as well, with their characteristic Latakia smell