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It sensitizes the peripheral nervous system, and nociceptive thresholds in smokers (and those exposed to secondhand smoke) tend to decrease (compared to non-smokers), increasing pain reactivity and perceived pain (learn more about pain sensitization)

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Harmful Chemicals in Electronic Cigarettes Cessation Support for Students Wish you could quit vaping

This is also supported by the fact that lung cancer is a frequent co-morbidity of COPD, a major inflammatory lung disease caused by smoke exposure

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