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There were 15 studies on the use of nicotine replacement [19, 20, 22,23,24, 29,30,31,32,33,34,35, 90,91,92], and four of 14 studies showed that smoking cessation did not alter circulating NOx levels [92], improved the function of EPCs but not the number of EPCs [24], did not improve FMD [91], and improved FMD but not RHI [34]

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According to a study by Humeniuk et al., published in Addiction (2008), the ASSIST demonstrated strong predictive validity, with a sensitivity of up to 97% in detecting substance-related disorders in clinical populations