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A., & Robble, M

Melatonin ameliorates the advanced maternal age-associated meiotic defects in oocytes through the SIRT2-dependent H4K16 deacetylation pathway

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These findings have positioned FOXO4-DRI as one of the most mechanistically specific senolytic peptides currently available for research purposes, distinguishing it from small-molecule senolytics that operate through broader cellular pathways

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Cureus 17(10): e94838