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Any related regulatory regime should include post-marketing surveillance to monitor the long-term effects of these products and ensure the FDAs actions have the intended health outcome of significantly reducing disease and death. Although the American Cancer Society remains conservative in regards to electronic cigarette use, its change in position compared to the year 2009 is quite significant

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The FDA in June 2022 also announced that JUULs applications lacked sufficient evidence regarding the toxicological profile of the products to demonstrate that marketing of the products would be appropriate for the protection of the public health. The agency has also recently noted that scientific issues unique to its application warrant additional review and stated that the company still cannot legally market or sell its products

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