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While nicotine upregulates the expression of IL8, the expression of IL1, IL6, TNF, MIP-1, MIP-1, and MCP-1 are downregulated

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In a In a 2019 study, researchers found that smokers with epilepsy were nearly 4 times more likely to experience seizures in the past year than nonsmokers

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Moreover, infections and inflammatory responses in the maternal system can lead to the release of cytokines and immune cells, which generate ROS (Yu et al., 2022)