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ISBN 978-0-7867-2190-0

Dispose of contents/container in accordance with local/regional/national/international regulations

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doi:10.1016/j.bbrc.2004.11.033

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ACCORDING TO THE WORLD Health Organization, there were approximately 1.3 billion smokers worldwide in 2003, and that number is expected to increase to 1.7 billion by 2020.1 It is estimated that about 1 billion people will die from smoking in the 21st century.2 Research conducted over the past several decades indicates that tobacco companies have engaged in extensive efforts, including developing genetically engineered tobacco to enhance nicotine delivery3 6 and using reconstituted tobacco and nicotine extracts, to manipulate cigarette nicotine levels and influence peoples smoking behaviors