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Sample size For a Williams crossover design with three products and six sequences, and an overall standard deviation (SD) of paired differences of 0.129 (comparable to an intra-participant coefficient of variation [CV] of 13%), it was calculated that a minimum of 30 participants would be needed to detect an 11% (0.11) difference between mean values with a statistical power of at least 80% and a significance level of 5%

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