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These can make allergies and asthma worse and may trigger flare-ups

It is worth noting that studies in animal models showed that exposing wild type mice to cigarette smoke compounds may cause pancreatic lesions, but it rarely reaches the pancreatic adenocarcinoma stage suggesting that smoking cooperates with other environmental and/or genetic factors such Kras mutation to induce pancreatic cancer

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One drawback of this procedure was that only a square-wave puff profile was achievable rather than the bell-shaped puff profile, which is typically specified by standardised machine-smoking methods [12, 13] and also approximated by human smokers

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