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[15] Serious but infrequent events-such as angioedema, bronchospasm, hypotension, or urticaria-reflect IgE-mediated hypersensitivity and may require desensitization or substitution with hydroxocobalamin

In modern times, our environment is more urbanized, and the food we eat and the water we drink has is pasteurized, sanitized, and modified until a significant amount of the nutrients that used to be naturally prevalent are now gone

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