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White, male and female Wistar rats, aged three months (average body weight: 361 g male and 189 g female), born and reared in the Animal House of the Department of Toxicology, at the Poznan University of Medical Sciences, Poznan, Poland, were housed in polypropylene cages (33 17.8 40 cm) (n = 1 rat/cage) with autoclaved pine sawdust litter under controlled environmental conditions (12 h light/dark cycle: 7 am7 pm

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