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However, stepping up to 6mg should be intentional, especially if you are trying to manage or gradually reduce total nicotine intake over time

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MOUTSCHEN-DAHMEN, J., MOUTSCHEN-DAHMEN, M., & EHRENBERG, L

(15) Other theories for biological mechanism linking smoking to TED have also been proposed: smoking may have a direct irritant action on the eye, causing inflammatory changes, smoking may be a cause of stimulation of the autoimmune process in smokers and smoking may be influence the secretion of cytokine in the eye