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The Combined Effects of Alcohol Consumption and Smoking on Cancer Risk by Exposure Level: A Systematic Review and Meta-Analysis 1 , 2 Hyunjin Park, 1 , 2 Ui-Jeong Kim, 1 Hye Ah Lee, 3 Bomi Park, 4 Soon Young Lee, 5 Sun Ha Jee, 6 and Hyesook Park 1 , 2 Abstract Background Alcohol consumption is a major risk factor for cancer, and when combined with smoking, the risk increases