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Reduced bone mass phenotypes seen in nicotine-treated mice were significantly increased following nicotine withdrawal, an outcome accompanied by significantly reduced serum levels of tartrate-resistant acid phosphatase, a bone resorption marker

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Alcohol Clin Exp Res 1997;21(4):613619

High potency THC Dabs Several times per day. The young man needed hospitalization and is still experiencing substance induced mania, 12 days after treatment began