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Aliment Pharmacol Ther (1999) 13:140311.10.1046/j.1365-2036.1999.00630.x 60 BrantSRPiccoMFAchkarJPBaylessTMKaneSVBrzezinskiAet alDefining complex contributions of NOD2/CARD15 gene mutations, age at onset, and tobacco use on Crohns disease phenotypes