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To help adult users to completely switch to alternative nicotine products, it is important the other alternatives provide effective nicotine delivery comparable or close to that of conventional/combustibles cigarettes 22,23

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However, MIF is a negative regulator of p53 expression and can protect the CSE-induced apoptosis of pulmonary vascular endothelial cells by combating p53-mediated caspase-dependent apoptosis pathways [121]