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Reduce nicotine use E-cigarettes allow you to carefully control your nicotine intake and gradually reduce it

The brain requires more nicotine over time to achieve the same pleasurable effects

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Net of covariates, including gender, age, marital status, years of schooling, hukou type, income, and employment status, the serial mediation model in Table 4 indicates an overall positive association between tobacco dependence and chronic disease risk (total effect, STDYX=0.051