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However, a significant difference was observed in the number of daily cigarettes smoked by patients in the ICU (14.8 4.3), inpatient care (10.0 4.4), and outpatient care (7.7 6.0) (p=0.023)

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Keywords: Addiction, Electronic nicotine delivery devices, Nicotine, Tobacco industry documents Introduction Tobacco dependence is understood to be a complex process that is primarily caused by the pharmacological effects of nicotine which activate nicotinic acetylcholine receptors in the brain leading to release of the neurotransmitter dopamine into the mesolimbic area, corpus striatum and frontal cortex

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While their discreet nature and reduced environmental impact appeal to many, they still face ongoing scrutiny from health advocates and regulators