When you smoke or vape, nicotine reaches the brain within 1020 seconds and binds to nicotinic acetylcholine receptors (nAChRs)
Primack BA, Carroll MV, Weiss PM, et al
Benowitz NL, Perez-Stable EJ, Herrera B, Jacob P 3rd (2002) Slower metabolism and reduced intake of nicotine from cigarette smoking in Chinese-Americans
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Thus, negative effects due to smoking do not necessarily affect MAR outcomes in patients undergoing ICSI treatment especially younger patients