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S.SzczepanskiS.et al (2017)
When IgG4-RD involves the central nervous system or surrounding areas, it may cause: Persistent headaches Eye pain or swelling Facial numbness Neurological symptoms like vision or hearing changes Chronic sinus problems These symptoms may resemble migraines, tension-type headaches, or sinus infections, which is why understanding the link between IgG4-RD and chronic headaches is essential
The production of ACPA is influenced by several factors, including genetics (specifically genes encoding HLA-DR/SEs/Shared epitopes), environmental elements, smoking habits, the presence of lymphoid-specific protein tyrosine phosphatase non-receptor type-22 (PTPN22), and certain infectious agents such as Porphyromonas gingivalis, Aggregatibacter Actinomycetemcomitans, and the Epstein-Barr virus
Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agent
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these are trial protocols only, as no licensed dosing schedules or UK SmPCs exist for either agent
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