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Some cross-sectional case studies have indicated that users, compared to non-users, exhibit increased sympathetic drive, higher low-density lipoprotein (LDL) oxidation, and elevated pro-inflammatory markers, suggesting a higher cardiovascular risk ( 78 )

A study of Korean cigarette smokers found that those who used HTPs were no more likely to quit smoking than those who only used combustible cigarettes, regardless of their cigarette smoking frequency 10