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Statistical methods Considering the prolonged (4-week) smoking abstinence rate, the number of smokers that quit smoking was extracted from each study, while the point smoking abstinence rate was extracted from graphs using the specific software GetData Graph Digitizer and then an all time-points meta-analysis (ATM) 12 was conducted to assess evidence at every time-point reported by the included studies

Participants also showed reductions in self-reported cigarette dependence (-45%), smoking frequency (-29%), and smoking intensity (-78%

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