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CBD showed strong inhibition of CYP2A6 activity in CYP2A6-overexpressing microsomes using either nicotine or cotinine as substrate, with IC 50,u values of 0.27 0.06 and 0.21 0.14 M for cotinine and 3HC formation, respectively (Table 1)

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High-Nicotine Electronic Cigarette Products: Toxicity of JUUL Fluids and Aerosols Correlates Strongly with Nicotine and Some Flavor Chemical Concentrations

The Future of Vaping Technology and Regulations The electronic cigarette industry continues to evolve rapidly