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This has led to gaps in the registration of specific extracts in certain European countries

Minor differences were observed between the HOPE cohort and the source population on the following characteristics: Slightly more women in the HOPE cohort had a PPD diagnosis (PR, 1.06 [95% CI, 1.06;1.06]), used antidepressant medication one year prior to delivery (PR, 1.03 [95% CI, 1.02;1.03]), were less likely to have received a hospital depression diagnosis one year prior to delivery (PR, 0.96 [95% CI, 0.96;0.97]), had more often a personal (PR, 1.07 [95% CI, 1.07;1.08]) or family history of psychiatric disorders (PR, 1.07 [95% CI, 1.07;1.08]), were more likely to have a cohabitant partner (PR 1.01 [95% CI, 1.01;1.01]), were more likely to have higher educational levels, were less likely to smoke during pregnancy (PR, 0.99 [95% CI, 0.99;1.00]), had more healthy BMI, and had fewer obstetric comorbidities (Obstetric Comorbidity Index 3 PR, 0.96 [95% CI, 0.95;0.96], GDM PR, 0.96 [95% CI, 0.96;0.96], macrosomia PR, 1.06 [95% CI, 1.06;1.07], SGA PR, 1.03 [95% CI, 1.03;1.04])

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(text rev.) ( DSM-IV-TR ) (American Psychiatric Association 2000), an adult must exhibit at least three of the primary symptoms of substance dependence, generally at any time during the same 12-month period