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But from a clinician standpoint, we need to take these opportunities to implement appropriate clinical guidelines to make these patients nonsmokers." The study was published online Nov

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Since PARP-1 activation is a prerequisite to initiate the parthanatos pathway 23 , we treated HBE cultures with the selective PARP-1 inhibitor BMN673 currently in clinical trials for cancer treatment 27 and exposed the cells to mainstream smoke

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