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Small airway disease is a transitional stage in the progression from normal airways to emphysema in severe disease, as demonstrated by the follow-up Parametric Response Mapping (PRM) study in the SPIROMICS cohort, which used inspiratory and expiratory HRCT scans to assess small airway disease (120, 125)

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In the beginning I was so depressed

Most of them were unmarked, or at least too encrusted to read, but Eaton had an idea what some of them might be, and he felt a surge of excitement

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