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Furthermore, increasing VTA DA neuron firing mimicked the effects of chronic nicotine exposure on decision-making measures, linking the behavioral alterations with the physiological changes to DA neurons we observed in nicotine-treated mice

Springer, Cham, pp 317

Our results suggest that in practice vapers who reported higher CPD generally start with higher nicotine strength e-liquids, but that perhaps some smokers are starting on strengths insufficient for their needs

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