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Statements Author contributions The authors have made equal contributions in the writing and revising of this mini review

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Among the 30 smokers (5 of them only had been carried out the determination after smoking-quitting) who have used the quitting article, the nicotine metabolite in the urine of 14 smokers has dropped down to the level of the non-smokers (0.970.24 g/mg nicotine metabolite, creatinine), the content of the nicotine metabolize in the urine of the other 16 smokers shows no change in comparison with that before smoking quitting