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77 Two studies found that the inclusion of any one of the three markers (cg05575921 in AHRR , cg03636183 in F2RL3 or cg06126421 in 6p21.33), improved lung cancer risk prediction as measured by the area under the curve (AUC) by 1-2% (AUC~0.79), 96,97 and one of these studies found that the improvement in AUC remained even after adjusting smoking status and pack-years