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Hugoson A, Rolandsson M

But by the middle of the 20th century, the widespread use of NSAIDs and the Helicobacter pylori infection had drastically altered our understanding of the causes of peptic ulcers [12]

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They could demonstrate that nicotine exposure alters the function of monocyte-derived DCs, including (1) antigen uptake : no significant change was observed in macropinocytosis, but endocytic and phagocytic properties of immature DCs were reduced

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High-affinity nAChRs are sensitive to nicotinic antagonists such as mecamylamine (56), and mediate nicotine reinforcement and cognition (36, 57), whereas low-affinity nAChRs are less nicotine-sensitive