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Earlier research by the authors of the current paper showed that at 6-10 ppm, the birth weight was reduced by a mean of 350 g, vs the birth weight when the exhaled CO2 was 5 ppm

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The study was supported by the National Center for Advancing Translational Sciences, National Institutes of Health, and a New York State Empire Clinical Research Investigator Program award.

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a pragmatic solution would be to permit only a single pack size of 20, which is now the minimum in many countries

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