Left untreated for long enough, carbon monoxide can lead to the development of a variety of different medical conditions, including chronic heart disease
This forest plot presents the estimated mean relative risk, its 95% uncertainty intervals (UI), and the data points underlying the estimates for ischemic heart disease in association with secondhand smoke exposure (two-star rating of the risk-outcome relationship)
Smokers with lower nicotine dependence were less likely to purchase cigarettes when graphic health warnings were present, while the graphic labels had no effect on smokers with a heavy nicotine dependence
doi: 10.1016/j.freeradbiomed.2014.01.015 12 KunchithapauthamKAtkinsonCRohrerB
However, many US and Chinese e-cig manufacturers copied his designs illegally, and as a result Hon Lik did not get the expected financial rewards for his invention (although some US manufacturers have recompensated him through out of court settlements)
NEO uses a PLA polymer cooler which only reduces vapor temperature without filtration