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The search was performed in multiple databases, including PubMed, Web of Science, and Embase, and was supplemented by manual searches using Google Scholar to ensure completeness

Updated: March, 13 2026 In late 2023, the Food and Drug Administration (FDA) removed 19 peptides from their FDA Category 1 list to FDA Category 2

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In addition, CHE is reported to bind to non-telomeric G-quadruplex sequences also in the promoters of other genes, which binds to G-quadruplexes at promoters of VEGFA, BCL2, and KRAS genes and downregulates their expression (Jana et al., 2017)