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The skin substitutes exposed to both cigarette smoke and solar rays presented an aged profile with a decreased protein expression of collagens, induced by the inhibition of Smad2 phosphorylation leading notably to a decrease in procollagen synthesis, and the activation of MMP activity

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Analysis from the Global Burden of Disease Study 2017 estimated that 63,822 pediatric ( 90% of infected individuals (Gudbjartsson et al., 2020