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See Local restrictions on flavored tobacco and e-cigarette products for a full report on local flavored tobacco policies

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More than half (56.8%) of youth and young adult e-cigarette users surveyed used disposable e-cigarettes most often in the past month while less than a quarter (22.7%) used cartridge-based, or pod mod, systems covered by FDA flavor restrictions

Studies that have evaluated changes to cytokines in response found increased TNF, IL-1, IL-3, IL-4, IL-6, IL-9, IL-10, IL-12p70, IL-13, IL-17, IFN, KC, GM-CSF, eotaxin, MIP-1, MIP-1, and RANTES in C57BL/6 mice exposed to PG and PG with nicotine for 3 days (71)

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