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* According to a report from Health and Medicine Division of the National Academies of Sciences, Engineering and Medicine (formerly the Institute of Medicine), ** (Source: Texas population, US

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CONCLUSIONS Despite the well-known risks associated with cigarette smoking in CD, we require more sophisticated big data type studies to further elucidate the true relationship between smoking and disease pathways, while accounting for the several negative cofactors found in active smokers which cast significant uncertainty on the magnitude of the direct effect of smoking on disease pathophysiology

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