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These very high temperatures result in combustion, or burning, which produces thousands of chemicals, most of which are harmful

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If the temperature is very high, the products lose and dry out

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Both Nicotiana rustica and Nicotiana tabacum are native only to the Americas, where mankind came across them about 18,000 years ago

Although oxidative stress is known to induce post-translational modifications/damage to mitochondrial proteins [25, 26], it is currently unknown whether mitochondrial structure and function in airway epithelial cells are affected by cigarette smoke [27, 28], and whether these changes are present in COPD epithelium