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Wigand was the first whistleblower from a major tobacco company to go on the record alleging B&W (and presumably others) used chemicals that were GRAS (Generally Recognized as Safe) to increase the addictiveness of their products and was portrayed by Russell Crowe in Michael Manns 1999 film The Insider

Preclinical models and human studies have demonstrated that nicotine has cognitive-enhancing effects and these effects of nicotine may be an important factor in vulnerability to Tobacco Use Disorder (TUD) and may also contribute to difficulty in quitting smoking

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Sectional differences played a part

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