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The only positive RCT is an early study showing that participants ( n = 15) with sleep issues reported having slept better after receiving a single dose of 160 mg CBD compared to placebo [31]

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Tobacco Control, 2010

doi: 10.1056/NEJM197305312882205

This upregulation builds an irreversible tolerance to nicotine, and even after an individual stops smoking, those receptors remain in the brain

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