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In addition to TLR4 activation, cigarette smoke contributes to the activation of the signaling pathways of the NLR family pyrin domain containing 3 (NLRP3), which plays an important role in the development of COPD [69,70]

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These five items about the frequency of communication between providers and pregnant women about e-cigarette use were found to have strong reliability (=0.88), and they explained 59.1% of the variability about this communication (Table 3)