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From a long-term perspective and the actual needs, the work of controlling the total amount must be carried out unremittingly

To induce acute liver injury, 4-week-old male offspring mice from each exposure group received an intraperitoneal (i.p.) injection of APAP (Sigma-Aldrich, MO, United States) at a dose of either 300 or 500 mg/kg body weight or an equal volume of phosphate-buffered saline (PBS) after 16 h of fasting

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Release of hydrogen peroxide (H 2 O 2 ) in CSE increases with the tar content of cigarettes and leads to progressive oxidative damage in BBB ECs TS is a major exogenous source of free radicals contained in both gaseous phase and tar, which can spawn sustained high levels of ROS (e.g., H 2 O 2 ) that may directly affect the BBB integrity

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