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In another investigation, a novel nanoformulation of paclitaxel-loaded cholic acid-functionalized star-shaped PLGA-d--tocopheryl polyethylene glycol 1000 succinate (TPGS) NPs (PTX-loaded CA-PLGA-TPGS NPs) was used intravenously in female nude mice (BALB/c-nu, 1520 g, 6 weeks old) revealed significant reduction in tumor growth in mice twelve days after treatment [198]