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In smokers, some single nucleotide polymorphisms have been identified that are associated with a reduced risk of developing chronic obstructive pulmonary disease 22

This can result in delays in the passage of food from the oesophagus to the stomach, causing acid reflux

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Premium tobacco brands are very slow now and theres a small minority of customers who will buy them. Trudy Davies, owner of Woosnam & Davies News, Llanidloes, Wales, says: Roll-your-own tobacco is our biggest area because shoppers cant afford readymade cigarettes anymore

It is not unusual for promotional material for movies distributed globally to differ according to the market, with well-documented examples in certain markets giving greater prominence to individual actors, often those who are white and male

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