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It is investigated in experimental models for its interaction with growth factor signaling, angiogenesis-related mechanisms, and cytoprotective process

Regulation of Melanogenesis: Factors such as UV exposure, hormonal changes, and inflammation can significantly influence melanogenesis, often leading to an increase in melanin production as a protective response

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Gastroenterology (2014) 146(7):173951.e14

However, it should be noted that supplementation of betaine in individuals with CBS deficiency, without sufficient dietary methionine restriction, leads to methionine excess with severe clinical consequences (Schwahn et al, 2019)