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It is driven by factors such as vascular endothelial growth factor (VEGF), transforming growth factor beta (TGF), EDN-1, fibroblast growth factor 2 (FGF-2) produced by mast cells, keratinocytes, and fibroblasts, stimulating endothelial cells [153, 154]

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doi.org/10.1002/14651858.CD009260.pub3 Hampton LH, Kaiser AP

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The mechanism involves Epithalon's interaction with nuclear DNA and transcriptional machinery

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