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Another possible contributor to the observed cigarette smoking-induced epidermal hyperkeratinization is nicotine which has also been shown to increase various differentiation markers including filaggrin, involucrin, TG1 in keratinocytes 19 mediated by the activation of nicotinic acetylcholine receptors abundant in the skin 28

deploy this system in plants and show that it can be harnessed to monitor gene expression

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Despite a continued decrease in cigarette smoking in the U.S., consumption of large cigars has increased substantially since the federal tobacco tax increased in 2009

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