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Ethics declarations Ethics approval and consent to participate This narrative review is based on previously conducted studies and does not contain any unpublished study with participants or animals

A person should talk to their health care providers before starting any form of NRT, especially if they: Have diabetes, heart disease, asthma, or stomach ulcer or a recent heart attack Have already been prescribed medication to quit smoking Are under the age of 18 Are pregnant Studies have shown that NRT is most effective when accompanied by community/peer support and mental health counseling

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Among these, oxidative stress, chronic inflammation, and EMT are the most studied drivers of carcinogenesis

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